The Western Female High School was founded in 1844 as one of two "twin sisters" secondary schools for young ladies in the then 15-year-old Baltimore City Public Schools system, along with the Eastern Female High School. Earlier in 1829, the first four "grammar" schools (today's elementary schools) were established by the newly organized B.C.P.S., two for boys and two for girls, one in each of the four quadrants of the smaller densely populated city that was Baltimore then.

Western has a statewide reputation extending back 175 years for academic excellence. Western High offers three academic programs/curriculums: the "Accelerated College Preparatory" ("A Course"), "College Preparatory", and the "Teacher Academy". Western's most rigorous academic program is the "Advanced College Preparatory" Program, ("The 'A' Course"), which was established in 1933 by a joint agreement between Western and the then also all-female Goucher College (formerly located on the 2400 block of St. Paul Street in the Charles Village neighborhood in northern Baltimore City and relocated in the 1950s to the northeast of Towson, the county seat of suburban Baltimore County).

Within the "Accelerated College Preparatory" program, students can finish four years of high school work in grade 9–11. During their 12th-grade year they are able to pursue advanced placement or college-level courses. Students who graduate from "The 'A' Course" may enter college or university with "advanced standing". This rigorous college preparatory program allows students to take honors course in subjects in which they demonstrate strength. The classes of 2003, 2004, 2005, 2006, 2007, 2008 and 2009 had a 100% four-year college acceptance rate. The W.H.S.'s "Teacher Academy" offers four classes that prepare students for a career in education. Western also annually produces championship athletic teams and prize-winning performing arts students and sponsors more than 40 different type of clubs, organizations, service groups and publications. In 2012, the news magazine U.S. News and World Report ranked Western High School as 912th nationally and 44th in Maryland as a "Silver Medal High School".

Western High School's graduation is traditionally held on a Saturday in even years and on a Sunday in odd years, in June. This is because it shares an athletic complex (namely the football field) with its brother school, Baltimore Polytechnic Institute. The girls wear white, ankle-length dresses and carry red roses during the commencement ceremony. For many years now, it has also been customary to release white doves at commencement. The dove, Western's school mascot, symbolizes the Western Lady, flying above the crowd with quiet dignity, gentility, poise, and elegance. The doves released at commencement circle over Western, then fly off, just as the graduates, having completed their Western experience, depart for college.

According to Wikipedia