As of the 2010 census, the CDP had a population of 208. The capital of the Havasupai Indian Reservation, Supai is the only place in the United States where mail is still carried out by mules.

Supai has been referred to as "the most remote community" in the contiguous United States by the U.S. Department of Agriculture. It is accessible only by helicopter, on foot or by mule. Supai is 8 miles (13 km) from the nearest road and has no automobiles in the community.

Tourists and some residents were evacuated from Supai and surrounding area on August 17 and 18, 2008, due to flooding of Havasu Creek complicated by the failure of the earthen Redlands Dam (subsequent to the main flooding event) after a night of heavy rainfall. Evacuees were taken to Peach Springs, Arizona.[9] More heavy rains were expected and a flash flood warning was put into effect, necessitating the evacuation, according to the National Park Service. The floods were significant enough to attract coverage from international media.

Damage to the trails, bridges, and campground was severe enough for Havasupai to close visitor access to the village, campground, and falls until the spring of 2009. Further flooding in 2010 resulted in damage to repairs made previously and closures effective until May 2011.

Supai can be reached by hiking 8 miles (13 km), descending 2,004 feet (611 m) in elevation from Hualapai Hilltop through the Hualapai Canyon. Alternatively, the AirWest Helicopters service schedules flights from Hualapai Hilltop to Supai. Hualapai Hilltop is located about 70 miles (110 km) from the community of Peach Springs, along paved BIA Road 18.

According to wikipedia