McCormick Place hosts numerous trade shows and meetings. The largest regular events are the Chicago Auto Show each February, the International Home and Housewares Show each March and the National Restaurant Association Annual Show each May.

As early as 1927, Robert R. McCormick, a prominent member of the McCormick family of McCormick Reaper fame, and publisher of the Chicago Tribune, championed a purpose-built lakeside convention center for Chicago. In 1958, ground was broken for a $35 million facility that opened in November 1960, and was named after McCormick, who died in 1955. The lead architect was Alfred Shaw, one of the architects of the Merchandise Mart. This building included the Arie Crown Theater, designed by Edward Durell Stone. It seated nearly 5,000 people and was the second largest theater (by seating capacity) in Chicago.

The original McCormick Place, completed in 1960, seen in 1966 from Lake Michigan

McCormick Place continued to expand in October 2017 with the opening of Wintrust Arena, a 10,387-seat arena situated on Cermak Road just north of the West Building. The new facility hosts DePaul University men's and women's basketball and the Chicago Sky of the WNBA. The new arena boasts 22 suites, 479 club seats, and 2 VIP lounges. In addition to Demon and WNBA basketball, the arena is equipped to host concerts, sporting events, meetings, and conventions in conjunction with the rest of the McCormick Place complex.Sporting events such as gymnastics and volleyball are also held in the McCormick Place buildings in addition to the arena.

According to wikipedia