Biltmore House, the main residence, is a Châteauesque-style mansion built by George Washington Vanderbilt II between 1889 and 1895 and is the largest privately owned house in the United States, at 178,926 square feet (16,622.8 m2) of floor space (135,280 square feet (12,568 m2) of living area). Still owned by George Vanderbilt's descendants, it remains one of the most prominent examples of the Gilded Age.

The Biltmore Estate licenses its name and design elements to a line of housewares, linens, and luggage called "Biltmore For Your Home", marketed exclusively by Belk stores.

The house has been featured in "Empires of the Smoky Skies", a scenario in Sid Meier's Civilization V.

The estate and its surrounding forest make up the setting of Robert Beatty's 2015 middle-grade novel Serafina and The Black Cloak and its sequels.

The grounds and buildings of Biltmore Estate have appeared in a number of major motion pictures and TV series.

According to wikipedia