Amoeba Music is an American independent music store chain with locations in Berkeley, San Francisco, and Hollywood, Los Angeles, California. It was founded in 1990 in Berkeley, California and remains in operation, having survived the decline of CD sales in the 2000s.

A second location in San Francisco opened on November 15, 1997 in the Haight-Ashbury district, near Golden Gate Park. It was located in the former 24,000-square-foot (2,200 m2) Park Bowl bowling alley. It regularly stocks upwards of 100,000 CDs, vinyl records, and audio cassettes, both new and used.

The stores also trade in movies, though secondarily to their music business. Each location has a smaller collection of movies on DVD, VHS, Laserdisc and Blu-ray. In addition, each store maintains a selection of music-related posters and artwork for purchase, as well as Amoeba-branded merchandise. The Hollywood location had an entire second floor dedicated to DVD and Blu-ray at its original location. In addition, Amoeba Music frequently holds free shows during store hours with locally and nationally known artists from a wide variety of genres.

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